AustralieFrV1, Main, Exploration, bibRecord, 005955

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Identifieur interne : 005955 ( Main/Exploration ); précédent : 005954; suivant : 005956

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Auteurs : Erica Warlick [États-Unis] ; KWANG WOO AHN [États-Unis] ; Tanya L. Pedersen [États-Unis] ; Andrew Artz [États-Unis] ; Marcos De Lima [États-Unis] ; Michael Pulsipher [États-Unis] ; Gorgun Akpek [États-Unis] ; Mahmoud Aljurf [Arabie saoudite] ; Jean-Yves Cahn [France] ; Mitchell Cairo [États-Unis] ; Yi-Bin Chen [États-Unis] ; Brenda Cooper [États-Unis] ; Abhinav Deol [États-Unis] ; Sergio Giralt [États-Unis] ; Vikas Gupta [Canada] ; H. Jean Khoury [États-Unis] ; Holbrook Kohrt [États-Unis] ; Hillard M. Lazarus [États-Unis] ; Ian Lewis [Australie] ; Richard Olsson [Suède] ; Joseph Pidala [États-Unis] ; Bipin N. Savani [États-Unis] ; Matthew Seftel [Canada] ; Gerard Socie [France] ; Martin Tallman [États-Unis] ; Celaettin Ustun [États-Unis] ; Ravi Vij [États-Unis] ; Lars Vindel V [Danemark] ; Daniel Weisdorf [États-Unis]

Source :

Blood [ 0006-4971 ] ; 2012.

RBID : Pascal:12-0207393

Descripteurs français

Pascal (Inist)
- Conditionnement atténué, Age, Personne âgée, Leucémie myéloïde chronique, Cellule hématopoïétique, Inhibiteur de la tyrosine kinase, Hématologie.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Age, Chronic myelogenous leukemia, Elderly, Hematology, Hematopoietic cell, Non myeloablative treatment, Tyrosine kinase inhibitor.

Abstract

Tyrosine kinase inhibitors (TKIs) and reduced intensity conditioning (RIC)/nonmyeloablative (NMA) conditioning hematopoietic cell transplants (HCTs) have changed the therapeutic strategy for chronic myelogenous leukemia (CML) patients. We analyzed post-HCT outcomes of 306 CML patients reported to the Center for International Blood and Marrow Transplant Research aged 40 years and older undergoing RIC/NMA HCT from 2001 to 2007: 117 (38%) aged 40 to 49 years, 119 (39%) 50 to 59 years, and 70 (23%) 60 years or older. The majority (74%) had treatment with imatinib before HCT. At HCT, most patients aged 40 to 49 years were in chronic phase (CP) 1 (74%), compared with 31% aged 60 years or older. Siblings were donors for 56% aged 40 to 49 years; older cohorts had more unrelated donors. The majority received peripheral blood grafts and RIC across all age groups. 3 year overall survival (54%, 52%, and 41%), day + 100 grade II-IV acute GVHD (26%, 32%, and 32%), chronic GVHD (58%, 51%, and 43%), and 1-year treatment-related mortality (18%, 20%, and 13%) were similar across ages. The 3-year relapse incidence (36%, 43%, and 66%) and disease-free survival (35%, 32%, and 16%) were inferior in the oldest cohort. Importantly, for CP1 patients, relapse and disease-free survival were similar across age cohorts. Allogeneic RIC HCT for older patients with CML can control relapse with acceptable toxicity and survival in TKI-exposed CML, especially if still in CP1.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350369

Affiliations:

Le document en format XML

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<author><name sortKey="Kwang Woo Ahn" sort="Kwang Woo Ahn" uniqKey="Kwang Woo Ahn" last="Kwang Woo Ahn">KWANG WOO AHN</name>
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</affiliation>
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<author><name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Chicago Medical Center</s1>
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<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Chicago Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>The University of Texas MD Anderson Cancer Center</s1>
<s2>Houston, TX</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>The University of Texas MD Anderson Cancer Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pulsipher, Michael" sort="Pulsipher, Michael" uniqKey="Pulsipher M" first="Michael" last="Pulsipher">Michael Pulsipher</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Utah Blood & Marrow Transplant Program</s1>
<s2>Salt Lake City, UT</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Utah Blood & Marrow Transplant Program</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Gorgun" last="Akpek">Gorgun Akpek</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Greenebaum Cancer Center, University of Maryland</s1>
<s2>Baltimore, MD</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">College Park (Maryland)</settlement>
<region type="state">Maryland</region>
</placeName>
<orgName type="university">Université du Maryland</orgName>
</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>King Faisal Specialist Hospital & Research Center</s1>
<s2>Riyadh</s2>
<s3>SAU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Arabie saoudite</country>
<wicri:noRegion>King Faisal Specialist Hospital & Research Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Hôpital Albert Michallon, Centre Hospitalier Universitaire de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cairo, Mitchell" sort="Cairo, Mitchell" uniqKey="Cairo M" first="Mitchell" last="Cairo">Mitchell Cairo</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>New York Presbyterian Hospital</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>New York Presbyterian Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Massachusetts General Hospital</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Massachusetts General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Brenda" sort="Cooper, Brenda" uniqKey="Cooper B" first="Brenda" last="Cooper">Brenda Cooper</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>University Hospitals Case Medical Center</s1>
<s2>Cleveland, OH</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University Hospitals Case Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Karmanos Cancer Institute, Wayne State University</s1>
<s2>Detroit, MI</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Detroit, MI</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Memorial Sloan-Kettering Cancer Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memorial Sloan-Kettering Cancer Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Princess Margaret Hospital</s1>
<s2>Toronto, ON</s2>
<s3>CAN</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Princess Margaret Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jean Khoury, H" sort="Jean Khoury, H" uniqKey="Jean Khoury H" first="H." last="Jean Khoury">H. Jean Khoury</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Emory University Hospital</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Emory University Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kohrt, Holbrook" sort="Kohrt, Holbrook" uniqKey="Kohrt H" first="Holbrook" last="Kohrt">Holbrook Kohrt</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Stanford Hospital & Clinics, Stanford University Medical Center</s1>
<s2>Santa Clara, CA</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Santa Clara, CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>University Hospitals Case Medical Center</s1>
<s2>Cleveland, OH</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University Hospitals Case Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Royal Adelaide Hospital/SA Pathology</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Royal Adelaide Hospital/SA Pathology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>Karolinska University Hospital</s1>
<s2>Stockholm</s2>
<s3>SWE</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>H. Lee Moffitt Cancer Center and Research Institute</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>H. Lee Moffitt Cancer Center and Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Vanderbilt University Medical Center</s1>
<s2>Brentwood, TN</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Vanderbilt University Medical Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
<affiliation wicri:level="4"><inist:fA14 i1="22"><s1>CancerCare Manitoba/University of Manitoba</s1>
<s2>Winnipeg, MB</s2>
<s3>CAN</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
<orgName type="university">Université du Manitoba</orgName>
</affiliation>
</author>
<author><name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name>
<affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Memorial Sloan-Kettering Cancer Center</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memorial Sloan-Kettering Cancer Center</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ustun, Celaettin" sort="Ustun, Celaettin" uniqKey="Ustun C" first="Celaettin" last="Ustun">Celaettin Ustun</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Hematology, Oncology, and Transplant, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name>
<affiliation wicri:level="1"><inist:fA14 i1="24"><s1>Barnes Jewish Hospital</s1>
<s2>St Louis, MO</s2>
<s3>USA</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Barnes Jewish Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vindel V, Lars" sort="Vindel V, Lars" uniqKey="Vindel V L" first="Lars" last="Vindel V">Lars Vindel V</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Rigshopitalet</s1>
<s2>Copenhagen</s2>
<s3>DNK</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel" sort="Weisdorf, Daniel" uniqKey="Weisdorf D" first="Daniel" last="Weisdorf">Daniel Weisdorf</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Division of Hematology, Oncology, and Transplant, University of Minnesota</s1>
<s2>Minneapolis, MN</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Minneapolis, MN</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Chronic myelogenous leukemia</term>
<term>Elderly</term>
<term>Hematology</term>
<term>Hematopoietic cell</term>
<term>Non myeloablative treatment</term>
<term>Tyrosine kinase inhibitor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Conditionnement atténué</term>
<term>Age</term>
<term>Personne âgée</term>
<term>Leucémie myéloïde chronique</term>
<term>Cellule hématopoïétique</term>
<term>Inhibiteur de la tyrosine kinase</term>
<term>Hématologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Tyrosine kinase inhibitors (TKIs) and reduced intensity conditioning (RIC)/nonmyeloablative (NMA) conditioning hematopoietic cell transplants (HCTs) have changed the therapeutic strategy for chronic myelogenous leukemia (CML) patients. We analyzed post-HCT outcomes of 306 CML patients reported to the Center for International Blood and Marrow Transplant Research aged 40 years and older undergoing RIC/NMA HCT from 2001 to 2007: 117 (38%) aged 40 to 49 years, 119 (39%) 50 to 59 years, and 70 (23%) 60 years or older. The majority (74%) had treatment with imatinib before HCT. At HCT, most patients aged 40 to 49 years were in chronic phase (CP) 1 (74%), compared with 31% aged 60 years or older. Siblings were donors for 56% aged 40 to 49 years; older cohorts had more unrelated donors. The majority received peripheral blood grafts and RIC across all age groups. 3 year overall survival (54%, 52%, and 41%), day + 100 grade II-IV acute GVHD (26%, 32%, and 32%), chronic GVHD (58%, 51%, and 43%), and 1-year treatment-related mortality (18%, 20%, and 13%) were similar across ages. The 3-year relapse incidence (36%, 43%, and 66%) and disease-free survival (35%, 32%, and 16%) were inferior in the oldest cohort. Importantly, for CP1 patients, relapse and disease-free survival were similar across age cohorts. Allogeneic RIC HCT for older patients with CML can control relapse with acceptable toxicity and survival in TKI-exposed CML, especially if still in CP1.</div>
</front>
</TEI>
<affiliations><list><country><li>Arabie saoudite</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Hovedstaden</li>
<li>Manitoba</li>
<li>Maryland</li>
<li>Rhône-Alpes</li>
<li>Svealand</li>
<li>Île-de-France</li>
</region>
<settlement><li>College Park (Maryland)</li>
<li>Copenhague</li>
<li>Grenoble</li>
<li>Paris</li>
<li>Stockholm</li>
<li>Winnipeg</li>
</settlement>
<orgName><li>Université du Manitoba</li>
<li>Université du Maryland</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Warlick, Erica" sort="Warlick, Erica" uniqKey="Warlick E" first="Erica" last="Warlick">Erica Warlick</name>
</noRegion>
<name sortKey="Akpek, Gorgun" sort="Akpek, Gorgun" uniqKey="Akpek G" first="Gorgun" last="Akpek">Gorgun Akpek</name>
<name sortKey="Artz, Andrew" sort="Artz, Andrew" uniqKey="Artz A" first="Andrew" last="Artz">Andrew Artz</name>
<name sortKey="Cairo, Mitchell" sort="Cairo, Mitchell" uniqKey="Cairo M" first="Mitchell" last="Cairo">Mitchell Cairo</name>
<name sortKey="Chen, Yi Bin" sort="Chen, Yi Bin" uniqKey="Chen Y" first="Yi-Bin" last="Chen">Yi-Bin Chen</name>
<name sortKey="Cooper, Brenda" sort="Cooper, Brenda" uniqKey="Cooper B" first="Brenda" last="Cooper">Brenda Cooper</name>
<name sortKey="De Lima, Marcos" sort="De Lima, Marcos" uniqKey="De Lima M" first="Marcos" last="De Lima">Marcos De Lima</name>
<name sortKey="Deol, Abhinav" sort="Deol, Abhinav" uniqKey="Deol A" first="Abhinav" last="Deol">Abhinav Deol</name>
<name sortKey="Giralt, Sergio" sort="Giralt, Sergio" uniqKey="Giralt S" first="Sergio" last="Giralt">Sergio Giralt</name>
<name sortKey="Jean Khoury, H" sort="Jean Khoury, H" uniqKey="Jean Khoury H" first="H." last="Jean Khoury">H. Jean Khoury</name>
<name sortKey="Kohrt, Holbrook" sort="Kohrt, Holbrook" uniqKey="Kohrt H" first="Holbrook" last="Kohrt">Holbrook Kohrt</name>
<name sortKey="Kwang Woo Ahn" sort="Kwang Woo Ahn" uniqKey="Kwang Woo Ahn" last="Kwang Woo Ahn">KWANG WOO AHN</name>
<name sortKey="Lazarus, Hillard M" sort="Lazarus, Hillard M" uniqKey="Lazarus H" first="Hillard M." last="Lazarus">Hillard M. Lazarus</name>
<name sortKey="Pedersen, Tanya L" sort="Pedersen, Tanya L" uniqKey="Pedersen T" first="Tanya L." last="Pedersen">Tanya L. Pedersen</name>
<name sortKey="Pidala, Joseph" sort="Pidala, Joseph" uniqKey="Pidala J" first="Joseph" last="Pidala">Joseph Pidala</name>
<name sortKey="Pulsipher, Michael" sort="Pulsipher, Michael" uniqKey="Pulsipher M" first="Michael" last="Pulsipher">Michael Pulsipher</name>
<name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name>
<name sortKey="Tallman, Martin" sort="Tallman, Martin" uniqKey="Tallman M" first="Martin" last="Tallman">Martin Tallman</name>
<name sortKey="Ustun, Celaettin" sort="Ustun, Celaettin" uniqKey="Ustun C" first="Celaettin" last="Ustun">Celaettin Ustun</name>
<name sortKey="Vij, Ravi" sort="Vij, Ravi" uniqKey="Vij R" first="Ravi" last="Vij">Ravi Vij</name>
<name sortKey="Weisdorf, Daniel" sort="Weisdorf, Daniel" uniqKey="Weisdorf D" first="Daniel" last="Weisdorf">Daniel Weisdorf</name>
</country>
<country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name>
</noRegion>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
</region>
<name sortKey="Socie, Gerard" sort="Socie, Gerard" uniqKey="Socie G" first="Gerard" last="Socie">Gerard Socie</name>
</country>
<country name="Canada"><noRegion><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
</noRegion>
<name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
</country>
<country name="Australie"><noRegion><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name>
</noRegion>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Olsson, Richard" sort="Olsson, Richard" uniqKey="Olsson R" first="Richard" last="Olsson">Richard Olsson</name>
</region>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Vindel V, Lars" sort="Vindel V, Lars" uniqKey="Vindel V L" first="Lars" last="Vindel V">Lars Vindel V</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

Reduced intensity conditioning is superior to nonmyeloablative conditioning for older chronic myelogenous leukemia patients undergoing hematopoietic cell transplant during the tyrosine kinase inhibitor era

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